The Best Probiotic Supplements for Gut Health on the Market

Many of us unintentionally fall into unhealthy eating habits in this fast-paced era, but we fail to understand the negative impact of such a lifestyle. Unhealthful food items have caused many health ailments like poor digestive health, low immune health, and weight gain, among many others.

In this regard, Probiotic supplements have gained popularity. Many people are taking probiotics supplements to boost their overall digestive health and immune system in today’s world.

Good digestion is the key to overall health, and better digestion starts with good bacteria.

You may find a plethora of the best probiotic supplements on the market when you search online. But you must not fall for any random probiotic supplement, as only a few of them are effective and help build good bacteria for improved gut health.

All manufacturers of probiotic supplements claim to provide actual results of better digestive health and many other health benefits, but in reality, only a few of them work.

To guide you, our research and editorial team has tried many probiotic supplements and conducted hours of research to find the best probiotic supplements.

Here is our ranking.

The Best Probiotic Supplements in 2022

Here is how we ranked the best probiotic supplements for 2022:

BioFitThis is one of the best probiotic supplements that promote better digestion and good bacteria
1MD Complete Probiotics1MD Complete Probiotics is a perfect formula that contains various strains to balance the gut bacteria and boost gut health
BiOptimizers P3-OMP-3 OM is a revolutionary blend of proven strains to improve digestion and immune function
BioTrust Pro-X10BioTrust Pro-X10 is a top probiotic supplement containing digestive enzymes and proven bacteria strains to enhance digestive health and immune function and help people lose weight.
Organifi BalanceOrganifi Balance is responsible for balancing good bacteria to promote gut health and better immune health.
LeanBiomeLeanBiome is one of the weight loss supplements that contain probiotics to support weight management and digestive health. This supplement also replaces harmful bacteria with good bacteria.
Nucific Bio-X4Nucific Bio-X4 promotes better digestive health, immune system, heart health, and weight loss and offers various health benefits to the user for overall health.
Gundry MD 24 Strain ProbioticGundry MD serves 24 billion CFUs to improve digestive and immune health. This probiotic supplement is a perfect blend of various bacterial strains to boost gut health.
Unify Health Labs Multi-GI 5The manufacturer of this supplement ensures to add proven probiotic strains to enhance digestion and reduce gas, constipation and bloating.
SeedSeed is a supplement that focuses more on science than virtual benefits and helps people tackle various health ailments.
VitaPost Probiotic 40-BillionThis probiotic supplement restores gut health by improving good bacteria levels.
Upwellness Probiotic+Probiotic Plus contains six proven bacterial strains and superfoods to support overall health and wellness.



BioFit comes on the priority of best probiotic supplements that come with many health benefits. Its seven natural gut healing ingredients stand out from other supplements that benefit the body in more than one way.

If you are unsure if your gut is healthy or not, few signs show it is required to incorporate the best probiotic supplement. Out of all, this BioFit has proven benefits to support digestion for various health benefits.

It is a popular dietary supplement formulated to boost your metabolism by improving gut health, further helping to lose weight. The manufacturer ensures to combine healthy bacterial strains to increase the good bacteria already present in the intestinal tract. Every strain is responsible for promoting the healthy gut biome, further supporting the overall weight loss regime and immune function.

Each serving of BioFit offers 6 billion colony-forming units CFU of probiotics that help eliminate harmful bacteria and ensure a healthy digestive system.

Overall the manufacturer has created this fantastic probiotic supplement to reduce bloating, support immune health, trigger weight loss, and boost digestive functions.

IngredientsLactobacillus Rhamnosus, Lactobacillus Casei, Lactobacillus Plantarum, Lactobacillus Acidophilus, Bacillus Subtilis, and Bifidobacterium Longum
Key Highlights
  • The manufacturer promise to add natural and proven probiotics to improve gut health
  • One can lose up to significant weight by taking BioFit regularly without changing the diet or exercise routine.
  • Provide a healthy dose of healthy bacterial strains
  • You need to take one capsule a day.
  • Money-Back Guarantee180 days

    1MD Complete Probiotics


    1MD Complete Probiotics help encourage the digestive tract’s microbial balance, promoting immune and gut health. It is a top-ranked probiotic supplement with a dose of 51 billion CFUs in each serving, making it the potent and best probiotic.

    The creators of Complete Probiotics added 11 robust probiotic strains, allowing a user to have better digestive and immune function. This probiotic supplement comes in delayed-release capsules to ensure probiotics reach the intestines safely and optimizes their effectiveness.

    It is a specially formulated probiotic recommended by 1MD nutrition’s gastroenterologist, Dr. David Kahana, who has an excellent experience. He focuses on two approaches, first providing the essential nourishment to improve overall health and secondly, using solid probiotics to promote immune health and gut bacteria to prevent digestive problems.

    Unlike most probiotic supplements, Complete Probiotics Platinum allows easy probiotics and nutrient absorption as the manufacturer uses a customized mechanism to enhance absorption.

    IngredientsLactobacillus acidophilus, Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium bifidum, Lactobacillus casei, Lactobacillus plantarum, Lactobacillus gasseri, Lactobacillus salivarius, Lactobacillus rhamnosus, Lactobacillus bulgaricus, and Lactospore (bacillus coagulans)
    Key Highlights
  • Increase nutrient absorption and provide digestive support
  • Reduce the risk of irritable bowel syndrome and maintain bowel movements
  • Reduce occasional digestive upset and infection-induced diarrhea
  • Support immune function and gastrointestinal lining
  • Money-Back Guarantee90 days

    BioTrust Pro-X10


    Thousands of people widely use BioTrust Pro-X10 to have better digestive balance and immune functions. This probiotic supplement claims to be an advanced supplement with probiotic strains and prebiotics. When it comes to purchasing probiotics, people consume them due to their core benefit of supporting a healthy balance of gut bacteria.

    According to its official website, this dietary formula promises to balance the gut microbiome and provide an extra gut health boost.

    While you want a probiotic supplement that contains probiotics protected by acid-resistant technology to protect from stomach acid, allergic reactions, or bile acids, nothing is better than BioTrust Pro-X10.

    Each serving of this supplement offers 10 billion colony-forming units, which is a good starting point for optimal health.

    According to the manufacturer, BioTrust Pro X10 can help deal with various health aspects from low energy, brain fog, and weight loss.

    IngredientsBifidobacterium breve, Bifidobacterium lactis, Lactobacillus acidophilus, Lactobacillus plantarum, PreforPro and Lactobacillus rhamnosus
    Key Highlights
  • It contains clinically proven probiotics to boost digestive health and immune function
  • It features PreforPro that promotes the growth of probiotics
  • The synbiotic formula of prebiotics and probiotics
  • Reduce bloating issues, high-stress levels, digestive issues, and other gut starting issues
  • Money-Back Guarantee60 days

    BiOptimizers P3-OM


    If you have an unhealthy gut, you may experience inflammation problems that do not always seem to be related to digestive health. Though digestive issues, constipation, bloating, gas, and abdominal pain are apparent, indigestion issues, depression, fatigue, brain fog, and weight gain may also be a sign of unhealthy digestion.

    No matter what, to deal with overall digestive health to support your wellbeing. BiOptimizers P3-OM is the right choice. It is one of the top-rated probiotic supplements to improve your health.

    Each capsule of this supplement contains a potent blend of probiotics and prebiotics to support digestion in multiple ways. You must know that probiotic bacteria require prebiotic fiber to thrive, so when you intake BiOptimizers P3-OM, you are sure about the survival of probiotic ingredients in the body.

    The beauty of this probiotic supplement comes with a plethora of benefits, such as helping people build lean muscle mass, improve sleep quality, reduce mood swings, boost energy levels, and faster recovery from any health ailment, among many others.

    IngredientsLactobacillus Plantarum OM, rice bran, and vegetable capsules
    Key Highlights
  • Supports gut barrier and nutrient absorption
  • Optimize digestive function and relieves digestive symptoms
  • Controls the growth of bad bacteria, viruses, and yeasts in the gut
  • Improves weight loss and supports healthy immune function
  • Money-Back Guarantee365 days

    Organifi Balance


    Organifi Balance is well crafted for daily digestion; whether you need daily support or just an occasional pick, Organifi will offer you amazingly proven health benefits. Unlike other probiotic supplements, Organifi comes in a powdered form. The manufacturer ensures to add USDA organic and clinically proven ingredients to support the digestive system in multiple ways.

    It is a perfect balance of probiotic strains and prebiotic fiber that supports digestive tract and immune health. The creators have added five science-backed strains to improve digestion and prevent digestive problems.

    Organifi Balance is a perfect way to nourish and support your microbiome on any day. You can take this powdered probiotic supplement anytime in the morning, day or night. Also, thanks to a synergistic combination of widely used strains, it reduces bloating and stomach discomfort.

    Since Organifi is a trusted name in the dietary supplements space, they ensure to provide high quality and natural supplements which are safe to take. Each serving of Organifi Balance comes with 25 billion CFUS and five specific probiotic strains to improve gut health and reduce gas, bloating, and stomach acid, among many other benefits.

    Organifi Balance is one of the best probiotics for optimal health.

    IngredientsLactobacillus Rhamnosus, Lactobacillus Paracasei, Saccharomyces Boulardii, Lactobacillus Acidophilus, and Jerusalem artichoke
    Key Highlights
  • Include prebiotic fiber to increase the beneficial bacteria
  • Prevent and protect against harmful bacteria
  • Support brain health and immune function
  • Improve daily digestion and intestinal health
  • Money-Back Guarantee60 days



    LeanBiome is a popular probiotic supplement; it is a scientifically proven blend of dietary and prebiotic fibers. People who are willing to have a lean body with good bacteria can rely on LeanBiome.

    LeanBiome is a clinically backed prebiotic for lean body composition. According to studies, improved gut health drastically helps you lose weight effectively. Regarding such studies, the manufacturer of LeanBiome has created this blend to improve digestive system and gut health.

    Each capsule of LeanBiome contains proven multi-strain probiotics to help you in weight loss and promote gut health. The supplement offers multiple benefits like better metabolism, reduced hunger, and reduced body fat by diversifying the gut microbiomes.

    IngredientsLactobacillus gasseri, Lactobacillus rhamnosus, Lactobacillus fermentum, and Greenselect Phytosom
    Key Highlights
  • Promote weight loss regime and immune system
  • Enhance the digestive system to improve gut health
  • Suppress hunger and help people to intake less sugar and calories
  • EFSA approved ingredients and has no foul odor
  • Money-Back Guarantee180 days

    Nucific Bio-X4


    Nucific Bio-X4 is one of the probiotic supplements that help your weight management. It is a specially formulated supplement that contains four scientifically backed ingredients to prevent weight gain in numerous ways.

    This supplement comes under the weight loss supplement category and has numerous weight loss properties. Proven ingredients added by the creators are probiotics, prebiotics, digestive enzymes, and green tea extract, responsible for boosting metabolism, suppressing hunger, and helping indigestion.

    The formula effectively supports the overall digestive system and optimal wellness straightforwardly. It is a unique supplement on this list that promotes weight loss and digestion in numerous ways. Each serving of Nucific Bio-X4 contains 12 billion CFUs, from five potent probiotic strains.

    IngredientsCaralluma Fimbriata, EGCG, Amylase, Lipase, and Bromelain (digestive enzymes), Lactobacillus and Bifidobacterium strains of probiotics
    Key Highlights
  • Break down the food you eat and suppress hunger
  • Help in managing weight and reducing belly fat significantly
  • Boost metabolism and balance your gut bacteria
  • Support smoother digestion and ease digestive issues
  • Money-Back Guarantee90 days

    Gundry MD 24 Strain Probiotic


    Another diverse option on our list of probiotic supplements is Gundry MD 24 Strain Probiotic. This is known as the most potent formula of probiotics on the market. Thanks to its combination of 24 unique probiotic strains, it has helped thousands of people.

    Each probiotic strain is designed to help balance the gut bacteria and allow good bacteria to survive and thrive. It is formulated to get the right source of bacteria for overall gut health.

    Gundry MD 24 Strain probiotic is loaded with 30 billion colony-forming units of powerful probiotics to ensure smoother digestion.

    IngredientsBifidobacterium Bifidum, Saccharomyces Boulardii, Lactobacillus Plantarum, and Lactobacillus Rhamnosus
    Key Highlights
  • Help in smoother, more comfortable, and more regular digestion
  • Enhance energy levels and focus
  • Ensure a balanced and nourished digestive system
  • Boost immune system and overall health
  • Money-Back Guarantee90 days

    Unify Health Labs Multi-GI 5


    Unify Health Labs Multi-GI 5 is one of the probiotic supplements that restore gut health with proven ingredients. A revolutionary new formula promotes five critical health aspects: improved digestive system, weight management, better energy levels, healthy gastrointestinal lining, and balanced gut flora.

    As we all know, good health starts with the gut; keeping this in mind Unify Health Labs has manufactured this Multi-GI 5 with the proprietary blend for total support. Prebiotics, probiotics, and a unique GI health blend. All blends present in the formula soothe and support digestive balance and help your body naturally combat leaky gut issues.

    You have come to the right place if you suffer from low energy levels, stomach discomfort, weight gain, or other health issues. Multi G15 is a whole-body support formula designed to help you look much better than before.

    IngredientsOligosaccharides (Inulin from chicory root), Fermented L-Glutamine, Zinc-Carnosine Complex, Magnesium Beta-Hydroxybutyrate, Deglycyrrhizinated Licorice Root Extract (<1% Glycyrrhizic Acids), Black Pepper Extract (fruit) (BioPerine®), Berberine Hydrochloride, Lactobacillus gasseri, Bacillus coagulans (as ProDURA®), Lactobacillus casei, and Lactobacillus Plantarum
    Key Highlights
  • It is a total gut health formula with fermented foods proven to improve gut health.
  • Boost energy level and mental focus
  • Reduce gas, bloating, and stomach discomfort
  • Combat food cravings and help in weight management
  • Money-Back Guarantee90 days



    Seed is a daily symbiotic formula that contains 24 strain probiotics formulated for systematic health and engineered to survive acid, enzymes, moisture, and heat. This supplement focuses more on science than virtually any other probiotic supplement.

    It is a high-powered formula that promotes gastrointestinal health and whole-body support. Seeds are a probiotic that offers various health benefits like enhanced cardiovascular health, immune functions, better skin health, and help women to boost vaginal health.

    IngredientsBifidobacterium longum, Bifidobacterium infant, Bifidobacterium breve, Bifidobacterium lactis, Limosilactobacillus reuteri, Ligilactobacillus salivarius, Limosilactobacillus fermentum, Lacticaseibacillus rhamnosus, Lactiplantibacillus plantarum, and Lacticaseibacillus casei
    Key Highlights
  • Help in weight management and allow a person to lose weight effectively
  • Boost overall digestive functions and gut health
  • Improve immune system and overall wellness
  • Beyond digestive issues, it supports whole-body health
  • Money-Back Guarantee30 days

    VitaPost Probiotic 40-Billion


    VitaPost Probiotic 40-Billion rejuvenates the digestive flora to enhance the good bacteria levels to support better immune function, healthy digestive system, and overall health.

    Every strain added to the supplement is chosen considering its benefits and can work together with other strains. The manufacturer has added four potent strains that deliver 40 billion CFUs in each serving to replenish the gut.

    Ingredientslactobacillus acidophilus, Bifidobacterium lactis, Lactobacillus plantarum, and Lactobacillus paracasei
    Key Highlights
  • Reduce bloating, gas and constipation
  • Improve digestion and immune system
  • Support overall health and wellness
  • Keto and vegan-friendly supplement
  • Money-Back Guarantee30 days

    UpWellness Probiotic +


    Upwellness Probiotic+ is a physician formulated probiotic-containing six proven strains and three superfoods blends. It is designed to reduce bloating and boost energy, mood, and digestion, among many other benefits. It provides a daily dose of fiber to enhance digestion and gut health.

    Probiotic plus offers digestive enzymes, fiber, prebiotics, and probiotics to support overall health.

    Ingredientslactobacillus acidophilus la-14, lactobacillus rhamnosus, lactobacillus Plantarum lp-115., bifidobacterium bifidum bb-06, bifidobacterium breve bb-03, and saccharomyces boulardii.
    Key Highlights
  • Allow users to lose weight and manage weight
  • Boost better immune function and digestive health
  • Increase antibodies to promote immune health
  • Promote a balanced microbiome
  • Money-Back Guarantee30 days

    Scientific Evidence For Probiotics

    You may find much scientific evidence that shows the efficacy and safety of the best probiotics. According to studies, probiotic supplements ensure better digestive health, immune function, and weight loss and offer many other benefits.

    According to the review stated by the National Institute of Health, it is found that many probiotic strains are responsible for various health benefits. Common probiotic strains are Lactobacillus, Bifidobacterium, and Saccharomyces boulardii, usually found in many supplements.

    • Such strains are effective in
    • Prevent various infections, allergic reactions, or acne
    • Help in building colics in infants
    • Boost your body’s immune function
    • Ensure better gut health and deal with diarrhea, stomach pain, irritable bowel syndrome, bloating, and constipation
    • Produces various beneficial bacteria to improve overall digestion
    • Replace harmful bacteria with good bacteria

    Probiotics are also found in the body, affecting the entire body. 80% of our immune system is filled with probiotics, which play a vital role in every aspect of the body. When one takes a probiotic supplement to improve gut health, the body naturally acts as a defense against many health issues.

    According to various studies, it is also shown that probiotic supplements, when added to a regular diet, help to prevent diarrhea, ulcerative colitis, urinary tract infections, vaginal infection, and many other health issues.

    Researchers from Harvard state that different bacterial strains have a diverse impact on the body. Taking any specific probiotic strain will not help in various benefits. Some strains are more potent than others, and some may only impact certain body regions. You can always choose a probiotic supplement that contains different strains.

    Probiotics also play an essential role in nutrition. According to evidence, probiotic supplements are responsible for balancing the bacteria levels in the gut that further restore the good bacteria. A healthy gut balance shows impressive results from weight loss to better energy levels and a better immune system.

    Researchers also found probiotics are a great option to prevent diarrhea. A study indicates that probiotics can lower the chance and duration of diarrhea. Even in children, probiotics were found to reduce the risk of diarrhea by 57%.

    Another research also states that probiotic bacteria are also connected to better mental health. People who take probiotics tend to have better memory, and it reduces the risk of mental fog and cognitive decline. Research shows people who are having high-stress levels or suffering from depression, probiotics can help them reduce the symptoms.

    After taking Bifidobacterium and Lactobacillus strains regularly for two months, studies show drastic and significant improvement in cognitive health.

    You must have seen many people use probiotics to lose weight. Fortunately, this is a scientifically proven benefit of probiotics. Probiotics are effective for people who want to lose weight in numerous ways. Some strains are effective in blocking the hunger hormone and reducing cravings. Researchers also discovered that taking a low probiotic dosage of Lactobacillus gasseri strain significantly reduces belly fat.

    Overall, probiotics available in the market contain various clinically proven strains and are scientifically backed by many studies to help improve digestive health in many ways.

    FAQs About Probiotics

    We have received plenty of questions regarding probiotics and how do they work? To help you, we have answered many frequently asked questions.

    Q: What are probiotics?

    A: Probiotics are live bacteria present in your gut. According to studies, there are many health benefits of probiotic organisms.

    Q: Who should be taking probiotics?

    A: Usually, people facing digestive issues, low immunity, and more should consume probiotics.

    Q: What is the role of probiotics?

    A: The primary role of probiotics is to restore gut flora, which helps to balance bacteria levels in the gut.

    Q: When should I take probiotics?

    A: You can take probiotics at any time of the day. However, experts recommend taking probiotics 15 to 30 minutes before a meal.

    Q: Can we lose weight with the help of probiotics?

    A: Yes, probiotics help better digestion, which further helps lose weight. Many people take probiotics only for weight loss.

    Q: Do we have any food items for probiotics?

    A: Yes, various food items can improve good bacteria in the body naturally; they are sour curd, fermented foods, cheeses, sourdough, and kefir.

    Q: Can probiotics make you poop?

    A: Probiotics improve bowel movements to support overall digestive health. It may help you to poop and also relieves constipation.

    Q: What are CFUs?

    A: CFUs are known as colony-forming units. More CFUs in a probiotic means more live cultures will enter the body.

    The Best Probiotic Supplements in 2022 Final Words

    Probiotics are popular and proven ways to improve digestive health, gut health, immunity, weight loss, etc. Studies show that probiotics have multiple benefits, from better nutrition to better heart health to allergy defense.

    To purchase the best probiotic supplements, check out the stated list. Every supplement is proven to change one’s overall health.

    RELATED:Best Apple Cider Vinegar Products: Top ACV Supplement Brands to Buy

    Affiliate Disclosure:

    The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team. Please know we only recommend high-quality products.


    Please understand that any advice or guidelines revealed here are not even remotely substitutes for sound medical or financial advice from a licensed healthcare provider or certified financial advisor. Make sure to consult with a professional physician or financial consultant before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary and are not guaranteed as the statements regarding these products have not been evaluated by the Food and Drug Administration or Health Canada. The efficacy of these products has not been confirmed by FDA, or Health Canada approved research. These products are not intended to diagnose, treat, cure or prevent any disease and do not provide any kind of get-rich money scheme. Reviewer is not responsible for pricing inaccuracies. Check product sales page for final prices.

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